Main
Regina H Reynolds
Key publications
Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases
NPJ Parkinson’s disease
N/A
2023
- Reynolds, RH, Wagen, AZ, Lona-Durazo, F, Scholz, SW, Shoai, M, Hardy, J, Gagliano Taliun, SA, Ryten, M
- Role: Co-first author, lead analyst and corresponding author.
- Analysis of local genetic correlations between neurodegenerative and neuropsychiatric disorders, with the aim of identifying genomic regions and genes that may drive pleiotropy.
Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body disorders
Acta Neuropathologica
N/A
2021
- Feleke, R, Reynolds, RH, Smith, A, Tilley, B, Gagliano Taliun, SA, Hardy, J, Matthews, PM, Gentleman, S, Owen , D, Johnson, MR, Srivastava, P, Ryten, M
- Role: Co-first author and analyst.
- Transcriptomic analysis of cell-type-specific changes in the Lewy body diseases.
Informing disease modelling with brain-relevant functional genomic annotations
Brain
N/A
2019
- Reynolds, RH, Hardy, J, Ryten, M, Gagliano Taliun, SA
- Role: First author.
- Review of conceptual advances in the generation of brain-relevant functional genomic annotations and among tools that allow integration of these annotations with genome-wide association summary statistics.
Moving beyond neurons: the Role of cell type-specific gene regulation in Parkinson’s disease heritability
NPJ Parkinson’s disease
N/A
2019
- Reynolds, RH, Botía, JA, Nalls, MA, International Parkinson’s Disease Genomic Consortium (IPDGC), System Genomics of Parkinson’s Disease (SGPD), Hardy, J, Gagliano Taliun, SA, Ryten, M
- Role: First author and lead analyst.
- Analysis of Parkinson’s disease common variation, with the aim of identifying cell types and pathways of importance to disease risk.
Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington’s disease model
Molecular and Cellular Neuroscience
N/A
2018
- Reynolds, RH, Petersen, MH, Willert, CW, Heinrich, M, Nymann, N, Dall, M, Treebak, JT, Björkqvist, M, Silahtaroglu, A, Hasholt, L and Nørremølle, A
- Role: First author, lead experimentalist and analyst.
Publications
aws-s3-integrity-check: an open-source bash tool to verify the integrity of a dataset stored on Amazon S3
GigaByte
N/A
2023
- Garcia-Ruiz, S, Reynolds, RH et al.
- Role: Adviser. Contributed to idea development and critiqued manuscript.
Genome-wide Analysis of Motor Progression in Parkinson Disease
Neurology Genetics
N/A
2023
- Martinez-Carrasco, A, Real, R, Lawton, M, Reynolds, RH et al.
- Role: Adviser. Reviewed and critiqued statistical analyses and manuscript.
Regional genetic correlations highlight relationships between neurodegenerative disease loci and the immune system
Communications Biology
N/A
2023
- Lona-Durazo, F, Reynolds, RH et al.
- Role: Analyst and advisor. Contributed to code base and critiqued manuscript.
Association between the LRP1B and APOE loci and the development of Parkinson’s disease dementia
Brain
N/A
2023
- Real, R, Martinez-Carrasco, A, Reynolds, RH et al.
- Role: Adviser. Critiqued manuscript.
The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases
Neurobiology of Disease
N/A
2023
- Chen, Z, Reynolds RH et al.
- Role: Author and analyst. Performed partitioned SNP-heritability analyses and contributed to writing of results.
The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data
NPJ Parkinson’s disease
N/A
2023
- Leonard, HL, Reynolds, RH et al. on behalf of The International Parkinson Disease Genomics Consortium (IPDGC) and The Global Parkinson’s Genetics Program (GP2)
- Role: Author and analyst. Contributed to creation of tools.
ensemblQueryR: fast, flexible and high-throughput querying of Ensembl LD API endpoints in R
arXiv
N/A
2023
- Fairbrother-Browne, A, Garcia-Ruiz, S, Reynolds, RH et al.
- Role: Adviser. Contributed to conceptrualisation and critiqued manuscript.
IntroVerse: a comprehensive database of introns across human tissues
Nucleic Acid Research
N/A
2022
- García-Ruíz, S, Gustavsson, EK, Zhang, D, Reynolds, RH et al.
- Role: Adviser. Critiqued manuscript.
Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects
Nature Communications
N/A
2022
- Krohn, L, Heilbron, K, Blauwendraat, C, Reynolds, RH, et al.
- Role: Analyst. Performed colocalisation analyses and gene expression analyses.
ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2
Bioinformatics
N/A
2022
- Gustavsson, EK, Zhang, D, Reynolds, RH, Ruiz, SG, Ryten, MR
- Role: Adviser. Performed beta testing and critiqued manuscript.
A genetic link between risk for Alzheimer’s disease and severe COVID-19 outcomes via the OAS1 gene
Brain
N/A
2021
- Magusali, N, Graham, AC, Piers, TM, Panichnantakul, P, Yaman, U, Shoai, M, Reynolds, RH et al.
- Role: Adviser. Reviewed and critiqued statistical analyses and manuscript.
Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease
Communications Biology
N/A
2021
- Fairbrother-Browne, A, Ali, A, Reynolds, RH et al.
- Role: Adviser. Advised on tools available for cell-type specificity and heritability analyses.
A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies
Neuropathology and Applied Neurobiology
N/A
2021
- Altmann, A, Ryten, M, Di Nunzio, M, Ravizza, T, Tolomeo, D, Reynolds, RH et al.
- Role: Analyst. Collated gene lists designed to capture microglial states.
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein
Cell Reports
N/A
2021
- Kara, E, Crimi, A, Wiedmer, A, Emmenegger, M, Manzoni, C, Bandres-Ciga, S, D’Sa, K, Reynolds, RH et al.
- Role: Analyst. Performed expression-weighted cell-type enrichment analyses.
Heritability enrichment implicates microglia in Parkinson’s disease pathogenesis
Annals of Neurology
N/A
2021
- Andersen, MS, Bandres-Ciga, S, Reynolds, RH et al.
- Role: Adviser. Reviewed and critiqued statistical analyses and manuscript.
Human-lineage-specific genomic elements: relevance to neurodegenerative disease and APOE transcript usage
Nature Communications
N/A
2021
- Chen, Z, Zhang, D, Reynolds, RH et al.
- Role: Analyst. Performed partitioned SNP-heritability analyses.
Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets
JAMA Neurology
N/A
2021
- Kia, DA, Zhang, D, Guelfi, S, Manzoni, C, Hubbard, L, Reynolds, RH et al.
- Role: Analyst. Involved in cell-type annotation of prioritised genes.
Modelling multifunctionality of genes with secondary gene co-expression networks in human brain provides novel disease insights
Bioinformatics
N/A
2021
- Sánchez, JA, Gil-Martínez, AL, Cisterna, A, García-Ruíz, S, Gómez-Pascual, A, Reynolds, RH et al.
- Role: Adviser. Reviewed and critiqued statistical analyses and manuscript.
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture
Nature Genetics
N/A
2021
- Chia, R, Sabir, MS, Bandres-Ciga, S, Saez-Atienzar, S, Reynolds, RH et al.
- Role: Analyst. Performed colocalisation analyses and gene expression analyses.
CoExp Web, a web tool for the exploitation of co-expression networks
Frontiers in Genetics
N/A
2021
- García-Ruíz, S, Gil-Martínez, AL, Cisterna, A, Jurado, F, Reynolds, RH et al.
- Role: Analyst. Involved in cell-type annotation of gene co-expression networks.
Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study
Lancet Neurology
N/A
2021
- Jabbari, E, Koga, S, Valentino, R, Reynolds, RH et al.
- Role: Analyst. Performed colocalisation analyses.
Genome-wide association studies of cognitive and motor progression in Parkinson’s disease
Movement Disorders
N/A
2021
- Tan, MMX, Lawton, MA, Jabbari, E, Reynolds, RH et al.
- Role: Adviser. Reviewed and critiqued statistical analyses and manuscript.
Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types
Science Advances
N/A
2021
- Saez-Atienzar, S, Bandres-Ciga, S, Langston, RG, Kim, JJ, Choi, SW, Reynolds, RH et al.
- Role: Adviser. Reviewed and critiqued statistical analyses and manuscript.
Differences in network controllability and regional gene expression underlie hallucinations in Parkinson’s disease
Brain
N/A
2020
- Zarkali, A, McColgan, P, Ryten, M, Reynolds, RH et al.
- Role: Adviser. Reviewed and critiqued statistical analyses and manuscript.
Dementia risk in Parkinson’s disease is associated with interhemispheric connectivity loss and determined by regional gene expression
NeuroImage: Clinical
N/A
2020
- Zarkali, A, McColgan, P, Ryten, M, Reynolds, RH et al.
- Role: Adviser. Reviewed and critiqued statistical analyses and manuscript.
Analysis of brain atrophy and local gene expression in genetic frontotemporal dementia
Brain Communications
N/A
2020
- Altmann, A, Cash, DM, Bocchetta, M, Heller, C, Reynolds, RH et al.
- Role: Analyst. Performed expression-weighted cell-type enrichment analyses.
Incomplete annotation of disease-associated genes is limiting our understanding of Mendelian and complex neurogenetic disorders
Science Advances
N/A
2020
- Zhang, D, Guelfi, S, Ruiz, SG, Costa, B, Reynolds, RH et al.
- Role: Analyst. Performed expression-weighted cell-type enrichment analyses.
Regulatory sites for known and novel splicing in human basal ganglia are enriched for disease-relevant information
Nature Communications
N/A
2020
- Guelfi, S*, D’Sa, K*, Botía, JA*, Vandrovcova, J, Reynolds, RH et al.
- Role: Experimentalist and analyst. Performed PCR validation of transcription and partitioned SNP-heritability analyses.
Genetic variability in response to amyloid beta deposition influences Alzheimer’s risk
Brain Communications
N/A
2019
- Salih, DA, Bayram, S, Guelfi, S, Reynolds, RH et al.
- Role: Analyst. Performed colocalisation analyses.
Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset
NPJ Parkinson’s disease
N/A
2019
- Billingsley, KJ, Barbosa, IA, Bandrés-Ciga S, Quinn, JP, Bubb, VJ, Deshpande, C, Botía, JA, Reynolds, RH et al.
- Role: Analyst. Performed expression-weighted cell-type enrichment analyses.
Variation at the TRIM11 locus modifies Progressive Supranuclear Palsy phenotype
Annals of Neurology
N/A
2018
- Jabbari, E, John, W, Tan, MMX, Maryam, S, Pittman, A, Ferrari, R, Mok, KY, Zhang, D, Reynolds, RH et al.
- Role: Analyst. Performed gene-based association testing and analysis of gene expression data.
Pre-prints
Pseudogenes limit the identification of novel common transcripts generated by their parent genes
bioRxiv
N/A
2022
- Gustavsson, EK, Sethi, S, Gao, Y, Brenton, J, Ruiz, SG, Zhang, D, Reynolds, RH et al.
- Role: Adviser. Critiqued manuscript.
Detection of pathogenic splicing events from RNA-sequencing data using dasper
bioRxiv
N/A
2021
- Zhang, D, Reynolds, RH, et al.
- Role: Adviser. Helped guide and troubleshoot feature selection for outlier detection of splicing events.
ERASE: Extended Randomization for assessment of annotation enrichment in ASE datasets
bioRxiv
N/A
2019
- D’Sa, K, Reynolds RH et al.
- Role: Analyst. Performed partitioned SNP-heritability analyses.
G2P: Using machine learning to understand and predict genes causing rare neurological disorders
bioRxiv
N/A
2018
- Botía, JA, Guelfi, S, Zhang, D, D’Sa, K, Reynolds, RH et al.
- Role: Adviser. Helped interpret the output of machine-learning-based models to distinguish disease genes from non-disease genes.